MCM6 Polyclonal Antibody (E-AB-10451)
For research use only.
| Verified Samples |
Verified Samples in WB: 293T, K562, NIH/3T3, Hela Verified Samples in IHC: Human cervical cancer, Human tonsil |
| Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human MCM6 |
| Abbre | MCM6 |
| Synonyms | DNA replication licensing factor MCM6, MCG40308, MCM6, MCM6 minichromosome maintenance deficient 6, MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, Mcm6, Minichromosome maintenance complex component 6, Minichromosome maintenance deficient (m, S. pombe) |
| Swissprot | |
| Calculated MW | 93 kDa |
| Cellular Localization | Nucleus. Binds to chromatin during G1 and detach from it during S phase. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. |
Other Clones
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Other Formats
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Unconjugated
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