MLANA Polyclonal Antibody (E-AB-19522)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human esophagus cancer |
| Dilution | IHC 1:40-1:250 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human MLANA |
| Abbre | MLANA |
| Synonyms | Antigen LB39 AA, Antigen LB39-AA, Antigen SK29 AA, Antigen SK29-AA, MAR1, MART 1, MART-1, MART1, MLAN A, MLANA, Melan A, Melan A protein, Melanoma antigen recognized by T cells 1, Melanoma antigen recognized by T-cells 1, OTTHUMP00, OTTHUMP00000021036, OTTHUMP00000021037 |
| Swissprot | |
| Cellular Localization | Endoplasmic reticulum membrane. Golgi apparatus. Golgi apparatus>trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Immunology, Tags and Cell Markers |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Melan-A is a melanocyte differentiation antigen,recognized by autologous cytotoxic T lymphocytes. Melan-A is also called MART-1 (melanoma antigen recognized by T cells). The Melan-A/MART-1 gene encodes this protein,20-22 kDa,associated with endoplasmic reticulum and melanosomes. The function of the protein is unknown. Melan-A,isolated as a melanoma-specific antigen,is a transmembrane protein,which is expressed in skin,retina and the majority of cultured melanocytes as well as in melanomas. Melan A is expressed in more than 85% of melanomas. |
Other Clones
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Other Formats
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Unconjugated
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