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For research use only.

Verified Samples Verified Samples in IHC: Human thyroid cancer, Human esophagus cancer
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Recombinant protein of human MMP12
Abbre MMP12
Synonyms EC 3.4.24.65,  HME,  ME,  MGC138506,  MME,  MMP 12,  MMP-12,  MMP12,  Macrophage elastase,  Macrophage metalloelastase,  Macrophage metaloelastase,  Matrix metallopeptidase 12 (macrophage elastase),  Matrix metalloprotease 12,  Matrix metalloproteinase-12,  Mmp12
Swissprot
Cellular Localization Secreted>extracellular space>extracellular matrix.
Concentration 0.8 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Cardiovascular,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin.
Other Clones

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Unconjugated

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