Monkey PLAU/uPA Antibody Pair Set (E-KAB-0660)
For research use only.
| Background |
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active , carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA ( high molecular weight uPA ) . HMW-uPA can be further processed into LMW-uPA ( low molecular weight uPA ) by cleavage of chain A into a short chain A ( A1 ) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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| Synonyms |
UPA, u-PA, ATF, URK, UP-A, Urokinase, Abbokinase
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| Swissprot | |
| Reactivity |
Monkey
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| Specificity |
Detects Monkey PLAU/uPA in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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