For research use only.
| Verified Samples |
Verified Samples in WB: Human fetal liver, Hela, Human fetal brain Verified Samples in IHC: Human lung cancer, Human esophagus cancer |
| Dilution | WB 1:500-1:2000, IHC 1:25-1:100 |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human MORF4L1 |
| Abbre | MORF4L1 |
| Synonyms | CG6363, Eaf3, Esa1p associated factor 3 homolog, FWP006, HsT17725, MEAF3, MO4L1, MORF related gene on chromosome 15, MORF-related gene 15 protein, MORFRG15, MRG15, Morf4l1, Mortality factor 4 like 1, Mortality factor 4 like protein 1, Mortality factor 4-like protein 1 |
| Swissprot | |
| Calculated MW | 41 kDa |
| Observed MW |
Refer to figures
The actual band is not consistent with the expectation.
Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane. |
| Cellular Localization | Nucleus. |
| Concentration | 1.1 mg/mL |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | MORF4L1 (also known as MRG15) and MORF4-related gene X (MRGX).The human MORF4 gene maps to chromosome 4q33-q34.1.MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines.The genes encoding MRG15 and MRGX map to chromosomes 15q24 and Xq22, respectively.MORF4, MORF4L1 and MRGX each contain a C-terminal leucine zipper.An association between MORF4L1, Rb (retinoblastoma tumor suppressor) and PAM14 (protein associated with MORF4L1) suggests a role for MORF4L1 in transcription regulation. |
Other Clones
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