Mouse ACE2 Antibody Pair Set (E-KAB-0718)

ACE2 is a member of the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases.    It catalyzes the cleavage of the decapeptide angiotensin I into angiotensin-(1-9) and angiotensin II (potent vasoconstrictor) into the vasodilator angiotensin-(1-7).    ACE2 is a type I membrane protein that functions as a carboxypeptidase.    It cleaves between a proline and a single hydrophobic/basic residue from the COOH-terminus of its substrates.   ACE2 is a zinc metalloprotease with considerable homology to angiotensin I-converting enzyme (ACE),both enzymes contain the typical HEXXH zinc-binding motif,ACE has two catalytic sites and ACE2 has only one,and ACE2 is not inhibited by ACE inhibitors captopril,lisinopril,and enalaprilat.    Studies in mice showed that disruption of ACE2 induced a severe cardiac contractility defect and increased angiotensin II levels in heart.    Human ACE2 has been identified as the receptor for SARS (severe acute respiratory syndrome)-coronavirus.

ACEH, ACEII

Mouse

Detects Mouse ACE2 in ELISAs

ELISA

-20℃

12 months

This ELISA kit applies to the in vitro quantitative determination of Mouse ACE2 concentrations in serum, plasma and other biological fluids.