Mouse BAFF/CD257 Antibody Pair Set (E-KAB-0594)
For research use only.
| Background |
B cell-activating factor ( BAFF ) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus ( SLE ) . Also , some SLE patients have increased levels of BAFF in serum. Therefore , it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
|
| Synonyms |
TNFSF13B, BLYS, TALL1, THANK, TNFSF20, ZTNF4
|
| Swissprot | |
| Reactivity |
Mouse
|
| Specificity |
Detects Mouse BAFF/CD257 in ELISAs
|
| Applications |
ELISA
|
| Storage |
-20℃
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| Expiration date |
12 months
|
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