Mouse OxLDL Antibody Pair Set (E-KAB-0682)

Receptor that mediates the recognition,internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells.  OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction,resulting in pro-inflammatory responses,pro-oxidative conditions and apoptosis.  Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release,monocyte adhesion and apoptosis.  In addition to binding oxLDL,it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells,thereby participating in cell-mediated antigen cross-presentation.  Also involved in inflammatory process,by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.  Also acts as a receptor for advanced glycation end (AGE) products,activated platelets,monocytes,apoptotic cells and both Gram-negative and Gram-positive bacteria.

CLEC8A, CLEC8ASLOX1, C-type lectin domain family 8 member A, hLOX-1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, LOX1, LOX-1, LOX1ox LDL receptor 1, LOXIN, OLR1

Mouse

Detects Mouse OxLDL in ELISAs

ELISA

-20℃

12 months

This ELISA kit applies to the in vitro quantitative determination of Mouse OxLDL concentrations in serum, plasma and other biological fluids.