Mouse PDGF-BB Antibody Pair Set (E-KAB-0684)
For research use only.
| Background |
PDGF-BB is a mitogen that was initially identified as simian sarcoma viral oncogene homolog. It belongs to the Platelet-Derived Growth Factor (PDGF) family which includes five members: PDGF-AA,PDGF-BB,PDGF-AB,PDGF-CC,and PDGF-DD. PDGF-AA,AB,and BB dimers are processed intracellularly and secreted as active dimers that readily activate PDGF receptors (PDGFRs). PDGF-BB exerts its biological functions through the activation of dimeric receptors that are made up of two structurally similar protein-tyrosine kinase receptor subunits (αα-,αβ-,or ββ-PDGFR). PDGF-BB induces VSMC dedifferentiation by the down regulation of contractile protein markers and the up regulation of MMP-2. In cutaneous remodeling,studies ex vivo revealed that PDGF-BB is a mitogen and chemoattractant for dermal fibroblasts. Abnormalities of PDGFR/PDGF are thought to contribute to a number of human diseases,especially malignancy. Autocrine signaling is a consequence of PDGF-BB overexpression,which is clearly implicated in the pathogenesis of dermatofibrosarcoma protruberans (DFSP).
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| Synonyms |
c-sis, IBGC5, PDGF2, PDGF-2, PDGFB, Platelet-derived growth factor subunit B, SIS, SSV, PDGFBB, PDGF-BB
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| Swissprot | |
| Reactivity |
Mouse
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| Specificity |
Detects Mouse PDGF-BB in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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| Introduction |
This ELISA kit applies to the in vitro quantitative determination of Mouse PDGF-BB concentrations in serum, plasma and other biological fluids.
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