NBN Polyclonal Antibody (E-AB-15798)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human liver cancer, Human gastric cancer |
| Dilution | IHC 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human NBN |
| Abbre | NBN |
| Synonyms | AT V1, AT V2, ATV, Cell cycle regulatory protein p95, FLJ10155, MGC87362, NBN, NBS, NBS 1, NBS1, Nbn, Nibrin, Nijmegen breakage syndrome, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, p95, p95 protein of the MRE11/RAD50 complex |
| Swissprot | |
| Cellular Localization | Nucleus. Nucleus, PML body. Chromosome, telomere. Localizes to discrete nuclear foci after treatment with genotoxic agents. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. |
Other Clones
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Other Formats
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Unconjugated
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