NFATC2 Polyclonal Antibody (E-AB-12800)
For research use only.
| Verified Samples |
Verified Samples in WB: Human brain |
| Dilution | WB 1:200-1:1000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human NFATC2 |
| Abbre | NFATC2 |
| Synonyms | AI607462, KIAA0611, NF ATc2, NF ATp, NF-ATc2, NF-ATp, NFAC2, NFAT 1, NFAT pre existing subunit, NFAT pre-existing subunit, NFAT transcription complex, NFAT1, NFAT1-D, NFATc2, NFATp, Nu, Nuclear factor of activated T cells cytoplasmic 2, cytoplasmic 2, preexisting component |
| Swissprot | |
| Calculated MW | 98 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Immunology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. |
Other Clones
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Other Formats
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Unconjugated
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