NLRP4 Polyclonal Antibody (E-AB-16628)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human thyroid cancer, Human prostate cancer |
| Dilution | IHC 1:50-1:200 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human NLRP4 |
| Abbre | NLRP4 |
| Synonyms | Cancer/testis antigen 58, CLR19.5, CT58, FLJ32126, leucine rich repeat and PYD containing 4, leucine rich repeat and pyrin domain containing 4, LRR and PYD containing protein 4, LRR and PYD domains-containing protein 4, NACHT, NALP4, NLR family, NLRP4, Nucleotide binding oligome, Nucleotide binding oligomerization domain, PAAD and NACHT containing protein 2, PAAD and NACHT-containing protein 2, PAN2, PYPAF4, PYRIN and NACHT-containing protein 2, PYRIN containing APAF1 like protein 4, pyrin domain containing 4, PYRIN-containing APAF1-like protein 4, Ribonuclease inhibitor 2, RNH2抗体 |
| Swissprot | |
| Cellular Localization | Cytosol, Extracellular region or secreted, extracellular exosome. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cell biology, Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes |
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