NUAK1 Polyclonal Antibody (E-AB-12986)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human lung cancer |
| Dilution | IHC 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human NUAK1 |
| Abbre | NUAK1 |
| Synonyms | AMP activated protein kinase family member 5, AMPK related protein kinase 5, AMPK-related protein kinase 5, NUAK family SNF1 like kinase, NUAK family SNF1-like kinase 1, NUAK1, Nuak1, Omphalocele kinase 1, Probable serine/threonine protein kinase KIAA0537 |
| Swissprot | |
| Cellular Localization | Cytoskeleton, microtubule cytoskeleton, Nucleus, fibrillar center, nucleoplasm, nucleus, Other locations: cytoplasm. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression.Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53.Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability.Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex.Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. |
Other Clones
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Unconjugated
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