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For research use only.

Verified Samples Verified Samples in WB: A172
Verified Samples in IHC: Human liver cancer, Human thyroid cancer
Dilution WB 1:200-1:1000,  IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications WB,  IHC
Clonality Polyclonal
Immunogen Recombinant protein of human PAK2
Synonyms C-t-PAK2,  CB422,  EC 2.7.11.1,  Gamma PAK,  Gamma-PAK,  Kinase,  hPAK65,  p21 (CDKN1A) activated kinase 2,  p21 (CDKN1A)-activated kinase 2a,  p21 activated kinase 2,  p21 protein (Cdc42/Rac)-activated kinase 2,  p21 protein Cdc42 Rac activated kinase 2,  p21-activated kinase 2
Swissprot
Calculated MW 58 kDa
Cellular Localization Cytoplasm and Nucleus. Cytoplasm>perinuclear region. Membrane. Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
Concentration 0.5 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Cell Biology,  Microbiology,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling.The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities.The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
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Unconjugated

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