PARD6A Polyclonal Antibody (E-AB-14283)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human gastric cancer, Human liver cancer |
| Dilution | IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human PARD6A |
| Abbre | PARD6A |
| Synonyms | 0710008C04Rik, 2610010A15Rik, PAR 6A, PAR-, PAR-6, PAR-6 alpha, Par 6 partitioning defective 6 C elegans homolog alpha, Par 6 partitioning defective 6 homolog alpha, Par 6 partitioning defective 6 homolog alpha C elegans, par-6 family cell polarity regulator alpha |
| Swissprot | |
| Cellular Localization | Cytoplasm. Cell membrane. Cell projection>ruffle. Cell junction>tight junction. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Other Clones
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Other Formats
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Unconjugated
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