PE Anti-Human CD192/CCR2 Antibody[K036C2] (E-AB-F1385D)
![PE Anti-Human CD192/CCR2 Antibody[K036C2] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
| Isotype | Mouse IgG2a, κ |
| Host | Mouse |
| Reactivity | Human |
| Applications | FCM |
| Clonality | Monoclonal |
| Abbre | CD192/CCR2 |
| Synonyms | CC-CKR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R |
| Swissprot | |
| Cellular Localization | Membrane |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience |
| Clone No. | K036C2 |
| Conjugation | PE |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation. |
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