PE/Cyanine5 Anti-Human CD156c(ADAM10) Antibody[11G2] (AN00355G)
![PE/Cyanine5 Anti-Human CD156c(ADAM10) Antibody[11G2] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
| Isotype | Mouse IgG1, κ |
| Host | Mouse |
| Reactivity | Human |
| Applications | FCM |
| Clonality | Monoclonal |
| Abbre | CD156c |
| Synonyms | MADM, KUZ, alpha-secretase |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Clone No. | 11G2 |
| Conjugation | PE/Cyanine 5 |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | CD156c, also known as a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein ubiquitously expressed on most cell types. It consists of multiple functional domains, including a N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembranous domain, and cytoplasmic domain. It is secreted as a precursor protein and becomes as the activate/mature form through removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 functions as metalloproteinase to cleave several molecules including Notch, pro-TNF-α, amyloid precursor protein, myelin basic protein, and type IV collagen. It mediates the release of several cell adhesion molecules such as vascular endothelial cadherin or L-selectin to regulate endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases. |
Other Clones
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Other Formats
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FITC
PE/Cyanine 5
PE/Elab Fluor®594
PerCP/Cyanine 5.5
Unconjugated
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