PE/Cyanine5 Anti-Mouse CD162 Antibody[4RA10] (E-AB-F1034G)
![PE/Cyanine5 Anti-Mouse CD162 Antibody[4RA10] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: PE/Cyanine 5
APC Biotin Elab Fluor®488 Elab Fluor®647 Elab Fluor®700 Elab Fluor®Violet 450 FITC None (AF/LE) PE PE/Cyanine 5 PE/Cyanine 5.5 PE/Cyanine 7 PE/Elab Fluor®594 PerCP/Cyanine 5.5 Unconjugated Show More
| Isotype | Rat IgG1, κ |
| Host | Rat |
| Reactivity | Mouse |
| Applications | FCM |
| Clonality | Monoclonal |
| Abbre | CD162 |
| Synonyms | CD162, P-selectin glycoprotein ligand 1, PSGL-1, Selectin P ligand, Selplg, PSGL1 |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Cell Adhesion, Immunology |
| Clone No. | 4RA10 |
| Conjugation | PE/Cyanine 5 |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L. |
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