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100Tests $ 185.00
50Tests $ 115.00
100Tests×2 $ 295.00
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For research use only.

Background CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.
Alternate Names MMR,  MR,  MRC1,  macrophage mannose receptor,  mannose receptor
Swissprot
Clone No
Host Rat
Reactivity Mouse
Isotype Rat IgG2a, κ
Isotype Control
Application
FCM;ICFCM
Cellular Localization
Membrane;Endosome
Form Liquid
Conjugation
PE/Cyanine 7
Conjugation information PE/Cyanine7 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 775 nm (e.g., a 780/60 nm bandpass filter).
Spectrum
Storage Buffer Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration date 12 months
Shipping Ice bag
Cat.No. Product Name Sizes
E-CK-A105 10×ACK Lysis Buffer 500mL , 200mL , 100mL
E-CK-A107 Cell Staining Buffer 500mL , 200mL , 100mL
E-CK-A109 Intracellular Fixation/Permeabilization Buffer Kit 500Assays , 100Assays , 50Assays
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APC

FITC

PE

PE/Cyanine 7

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