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For research use only.

Verified Samples Verified Samples in WB: Hela
Verified Samples in IHC: Human lung cancer
Dilution WB 1:500-1:2000,  IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications WB,  IHC
Clonality Polyclonal
Immunogen Recombinant protein of human PKM2
Abbre PKM2
Synonyms CTHBP,  Cytosolic thyroid hormone binding protein,  Cytosolic thyroid hormone-binding protein,  KPYM,  MGC3932,  OIP 3,  OIP-3,  OIP3,  OPA interacting protein 3,  Opa-interacting protein 3,  PK,  PK muscle type,  PK2,  PK3,  PKM,  PKM2,  Pyruvat,  Pyruvate kinase 2/3,  muscle type,  p58,  pykm
Swissprot
Calculated MW 58 kDa
Cellular Localization Cytoplasm. Nucleus. Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic actvity.
Concentration 0.6 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Epigenetics and Nuclear Signaling,  Metabolism,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.
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Unconjugated

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