PMS2 Monoclonal Antibody (ELAB6729-M)
For research use only.
| Host | Mouse |
| Reactivity | Human |
| Applications | IHC-P |
| Synonyms | PMS2 |
| Cellular Localization | nucleus |
| Tissue Specificity | Colon cancer |
| Storage | The concentrated should be stored at -20°C protecting from light,Valid for 12 months. |
| Shipping | Ice bag |
| background | PMS2 is a 96kDa mismatch repair protein that forms a heterodimer with MLH1 protein and is then activated in the presence of ATP. This complex coordinates the binding of other proteins that repair DNA errors that occur during cell division. Loss of PMS2 expression in tumor cells helped to identify hMLH1 mutation vectors and to determine whether they were suitable for mutational analysis. PMS2 defects are responsible for a small but significant proportion of colorectal cancers and a large proportion of tumors with microsatellite instability. PMS2 is associated with cases of the dominant genetic disease hereditary nonpolyposis colon cancer (HNPCC) and is commonly used in cancer studies together with MLH1, MSH2 and MSH6. |
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