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For research use only.

Verified Samples Verified Samples in IHC: Human breast cancer
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human PNN
Abbre PNN
Synonyms 140 kDa nuclear and cell adhesion-related phosphoprotein,  DRS,  DRS protein,  DRSP,  Desmosome-associated protein,  Domain-rich serine protein,  MEMA,  Melanoma metastasis clone A protein,  Nuclear protein SDK3,  PININ,  PNN,  Pinin,  SR like protein,  SR-like protein
Swissprot
Cellular Localization Nucleus speckle. Cell junction>desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
Concentration 1.2 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Epigenetics and Nuclear Signaling
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Pinin is a desmosomal associated protein involved with the maintenance of cell to cell adhesion of the epithelium. Pinin is a widespread protein and has been shown to play an important role in cell adhesion through its interaction with nuclear complexes. Pinin is also involved in pre-mRNA splicing through its interactions with a C-terminal RS domain of Cyclophilin G, a Moca type nuclear cyclophilin. Pinin becomes nuclear during the early stages of embryonic development and remains so throughout the entire period. Defects or lack of Pinin can be lethal at perinatal stages and causes defects in the cardiac outflow tract, axial skeleton, palate and dorsal dermis.
Other Clones

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Unconjugated

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