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For research use only.

Verified Samples Verified Samples in IHC: Human cervical cancer, Human brain
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human PNOC
Abbre PNOC
Synonyms N/OFQ,  N23K,  N23K/N27K,  Nociceptin,  Npnc1,  OFQ,  OFQ/N,  Orphanin FQ,  Orphanin FQ2,  PNOC,  PPNOC,  Pnoc,  Propronociceptin,  included,  nocistatin,  ppN/OFQ,  pre-pro-N/OFQ,  prepronociceptin,  pronociceptin
Swissprot
Cellular Localization Secreted.
Concentration 0.4 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Neuroscience
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Nociception, a pain response mechanism, occurs in response to stimuli that threaten the integrity of an organism. The first synapses produced as a result of the initiation of nociception are modulated by excitatory amino acids (glutamate and aspartate) and many peptides (substance P, CGRP, CCK, endogenous opioids). Nociceptin (also designated orphanin FQ) is a neuronal peptide that is similar to opioid peptides. Nociceptin activates KOR-3 (kappa-type opioid receptor, also designated ORL1), a G protein-coupled receptor. Although similar to dynorphin A, a kappa opioid peptide, nociceptin functions to make animals hyperreactive to nociceptive stimulations. Nociceptin is also involved in locomotor behavior and may be involved in the modulation of synaptic plasticity in learning and memory.
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Unconjugated

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