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For research use only.

Verified Samples Verified Samples in IHC: Human esophagus cancer, Human breast cancer
Dilution IHC 1:50-1:300
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse
Applications IHC
Clonality Polyclonal
Immunogen Fusion protein of human POLH
Abbre POLH
Synonyms DNA polymerase eta,  FLJ16395,  FLJ21978,  POLH,  Polh,  RAD30,  RAD30 homolog A,  RAD30A,  XP V,  XPV,  Xeroderma pigmentosum variant type protein,  polymerase DNA directed eta
Swissprot
Cellular Localization Nucleus. Accumulates at replication forks after DNA damage.
Concentration 1.08 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Cancer,  Epigenetics and Nuclear Signaling
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
Other Clones

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Unconjugated

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