PPM1A/PP2CA/PP2C-alpha Monoclonal Antibody (AN200133P)
For research use only.
| Verified Samples |
Verified Samples in IF: MCF7 Verified Samples in FCM: Jurkat |
| Dilution | ICC/IF 1:20-1:100, FCM 1:25-1:100, |
| Isotype | IgG2a |
| Host | Mouse |
| Reactivity | Human |
| Applications | FCM, ICC/IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human PPM1A / PP2C-alpha protein |
| Abbre | PPM1A |
| Synonyms | PPM1A, PP2C-ALPHA, PP2CA, PP2Calpha, Protein Phosphatase 1A, Protein Phosphatase 2C Isoform Alpha, Protein Phosphatase IA, PPPM1A |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Signal Transduction |
| Clone No. | 11B5 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G1/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. |
Other Clones
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Other Formats
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Unconjugated
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