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For research use only.

Verified Samples Verified Samples in IHC: Human liver cancer
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse
Applications IHC
Clonality Polyclonal
Immunogen Fusion protein of human PPM1M
Abbre PPM1M
Synonyms FLJ32332,  PP2C eta,  PP2C-eta,  PP2CE,  PP2Ceta,  PPM1M,  Protein phosphatase 1M,  Protein phosphatase 2C isoform eta,  protein phosphatase 1M (PP2C domain containing)
Swissprot
Cellular Localization Nucleus.
Concentration 0.78 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Signal transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background PPM1M is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42).
Other Clones

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Unconjugated

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