PPP1CC Polyclonal Antibody (E-AB-16728)
For research use only.
| Verified Samples |
Verified Samples in WB: Jurkat, 293T, Hela, Mouse brain, K562 Verified Samples in IHC: Human lung cancer, Human liver cancer |
| Dilution | WB 1:1000-1:5000, IHC 1:100-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human PPP1CC |
| Abbre | PPP1CC |
| Synonyms | PP 1G, PP-1G, PP1C, PP1G, PP1gamma, PPP 1G, PPP1CC, PPP1G, Protein phosphatase 1, Protein phosphatase 1C catalytic subunit, Se, Serine/threonine phosphatase 1 gamma, Serine/threonine protein phosphatase PP1 gamma catalytic subunit, catalytic subunit, gamma isozyme |
| Swissprot | |
| Calculated MW | 37 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Nucleus>nucleolus. Nucleus>nucleoplasm. Nucleus speckle. Chromosome>centromere>kinetochore. Cleavage furrow. Midbody. Colocalizes with SPZ1 in the nucleus (By similarity). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. |
| Concentration | 1.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily.PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division.It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns.This gene encodes the gamma isozyme.Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Other Clones
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Unconjugated
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