PRKCE Polyclonal Antibody (E-AB-60613)
For research use only.
Verified Samples |
Verified Samples in IHC: Rat spleen, Human esophageal cancer, Human stomach |
Dilution | IHC 1:50-1:200 |
Isotype | IgG |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Applications | IHC |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein of human PRKCE (NP_005391.1). |
Synonyms | PKCE, PRKCE, nPKC-epsilon |
Swissprot | |
Cellular Localization | Cytoskeleton, Cytosol, Endoplasmic reticulum, endoplasmic reticulum, Golgi apparatus, Golgi apparatus, Mitochondrion, Nucleus, Plasma Membrane, Other locations: cell periphery, cytoplasm, perinuclear region of cytoplasm. |
Concentration | 1 mg/mL |
Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method | Affinity purification |
Research Areas | Cancer, Signal Transduction |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
background | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. |
Other Clones
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Other Formats
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Unconjugated
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