PRMT5 Polyclonal Antibody (E-AB-12625)

Name: PRMT5 Polyclonal Antibody
Brand: Elabscience
SKU: E-AB-12625
Price: 73.0 USD
Availability: InStock

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Size	Price	Qty
200μL	$ 399.00	- +
120μL	$ 240.00	- +
60μL	$ 143.00	- +
20μL	$ 73.00	- +

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Verified Samples	Verified Samples in WB: K562, Hela, 293T
Dilution	WB 1:200-1:1000
Isotype	Rabbit IgG
Host	Rabbit
Reactivity	Human, Mouse, Rat
Applications	WB
Clonality	Polyclonal
Immunogen	Synthetic peptide of human PRMT5
Abbre	PRMT5
Synonyms	72 kDa ICln binding protein, 72 kDa ICln-binding protein, ANM5, HMT1 hnRNP methyltransferase like 5, HOMOLOG OF, HRMT1L5, Histone synthetic lethal 7, Histone-arginine N-methyltransferase PRMT5, IBP72, JBP 1, JBP1, Jak-binding protein 1, S. cerevisiae, SKB1, homolog of
Swissprot	O14744
Calculated MW	71 kDa
Cellular Localization	Cytoplasm. Nucleus.
Concentration	0.3 mg/mL
Buffer	Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method	Affinity purification
Research Areas	Cancer, Epigenetics and Nuclear Signaling
Conjugation	Unconjugated
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping	The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background	Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.

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