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For research use only.
| Verified Samples |
Verified Samples in IHC: Rat heart, Human gastric cancer, Mouse spleen Verified Samples in IF: U2OS |
| Dilution | IHC 1:50-1:100, IF 1:50-1:100 |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human PTPN11 (NP_002825.3). |
| Synonyms | BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, PTPN11, SH-PTP2, SH-PTP3, SHP2 |
| Swissprot | |
| Cellular Localization | Cytoplasm. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. |
Other Clones
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Other Formats
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Unconjugated
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