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For research use only.

Verified Samples Verified Samples in IHC: Human cervical cancer, Human thyroid cancer
Dilution IHC 1:25-1:100
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human PTPN13
Abbre PTPN13
Synonyms APO1/CD95 (Fas) associated phosphatase,  DKFZp686J1497,  FAP 1,  FAP1,  Fas associated phosphatase 1,  Fas associated protein tyrosine phosphatase 1,  HGNC:9646,  PNP 1,  PNP1,  Phosphatase rip,  Protein tyrosine phosphatase 1 Fas associated,  hPTPE1,  protein tyrosine phosphata
Swissprot
Cellular Localization Cytoplasmic
Concentration 0.5 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Cell Biology,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
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Unconjugated

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