Purified Anti-Human CD103 Antibody[Ber-ACT8] (AN013280P)
| Alternate Names | A530055J10, alpha E, alpha E (antigen CD103, alpha polypeptide), alpha subunit, alpha-E1, alpha-M290, aM290, Antigen CD103, CD 103, CD103 antigen, epithelial-associated, HML 1 antigen, HML1 antigen, HML-1 antigen, Human mucosal lymphocyte antigen 1, Integrin, Integrin alpha E, Integrin alpha E heavy chain, Integrin alpha E light chain, Integrin alpha E1, Integrin alpha IEL, Integrin alpha M290, Integrin alpha-E heavy chain, Integrin alpha-IEL, ITAE, MGC141996, MGC183601, Mucosal lymphocyte 1 antigen, Mucosal lymphocyte antigen 1, ITGAE, CD103, HUMINAE, HML-1, &, alpha-E integrin-n, aIEL |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Human CD103 gene |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | CD103 is a type I transmembrane glycoprotein also known as αE integrin, integrin αIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Treg cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as an αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium. |
| Immunogen | Recombinant Human CD103 protein |
| Abbre | CD103 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21], Functional Grade |
| Applications |
FCM
|
| Research Areas | CDs;MAPK-Erk Signaling Pathway;PI3K-Akt Signaling Pathway;Signal Transduction;Stem Cells;Immunology;Hematopoietic Stem Cell Markers;Cytoskeleton |
| Cellular Localization |
Membrane
|
| Tissue Specificity |
Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
-
IF：{{item.impact}}
Journal：{{item.journal}} ({{item.year}})
DOI：{{item.doi}}Reactivity：{{item.species}}
Sample Type：{{item.sample_type}}
-
Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}}
No files available. Please enter the correct identification code in the search area to query the relevant documents.
| Title | Status | Valid until | Action | |
|---|---|---|---|---|
| {{v.文件名}} | {{v.status_str}} | {{v.timestamp_str}} | Download | / |
*Note：Please download the relevant files within the validity period. After expiration, file preview and download will not be available on the page.
Videos
Resources
Contact with Us
Toll-free: 1-888-852-8623
Tel: 1-832-243-6086
Add:
14780 Memorial Drive, Suite 105, Houston, Texas, 77079, USA
