Purified Anti-Human CD137L Antibody[C65-485] (AN013030P)
| Alternate Names | Tumor necrosis factor ligand superfamily member, TNFL, TNFSF, TNFSF9, 4-1BB-L, CD137L, TNLG5A, 4 1BB L, 4 1BB ligand, 4-1BB ligand, 4-1BBL, CD157L, ILA ligand (TNF related), Ly63l, TNFL9, Tumor necrosis factor ligand superfamily member 9 |
| Clone | |
| Verified Samples | Verified Samples in FCM: Hela |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | The C65-485 monoclonal antibody specifically recognizes the type II membrane protein known as 4-1BB Ligand (4-1BB-L) or CD137 Ligand (CD137L). This molecule belongs to the TNF superfamily and is encoded by TNFSF9 (Tumor necrosis factor superfamily member 9). CD137 Ligand has been reported to have costimulatory function on activated T cells. Reports suggest that stimulation of activated T cells via CD137 Ligand does not require the presence of other costimulatory molecules, including CD28. Some studies have reported human CD137 Ligand to be expressed preferentially on primary B cells and B-cell lines. The C65-485 antibody is able to react with recombinant human 4-1BB Ligand (rh4-1BB-L/CD137L) bound to CD137 (4-1BB receptor) expressed on phytohemagglutinin (PHA)-stimulated PBMC. |
| Immunogen | Recombinant Human CD137L protein |
| Abbre | CD137L |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21], Functional Grade |
| Applications |
FCM
|
| Research Areas | Immunology;Cancer;Cytokine and Growth Factors |
| Cellular Localization |
Membrane
|
| Tissue Specificity |
Expressed in brain, placenta, lung, skeletal muscle and kidney.
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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