Purified Anti-Human CD141 Antibody[1A4] (AN015560P)
| Alternate Names | AHUS, BDCA, THPH, THBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, Fetomodulin, Thrombomodulin |
| Clone | |
| Verified Samples | Verified Samples in FCM: A431 |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | CD141 is a 75 kDa, single chain, type I membrane glycoprotein referred to as thrombomodulin and fetomodulin. CD141 is expressed on endothelial cells, smooth muscle cells, epithelial cells, synovial lining cells, and keratinocytes. It is also found on megakaryocytes, dendritic cells, peripheral blood monocytes, and neutrophils, but not on lymphocytes. Reports indicate that CD141 plays an important role in Protein C activation and the initiation of the Protein C anticoagulant pathway. Thrombin loses its procoagulant function when it binds to CD141, and the CD141/thrombin complex is able to activate Protein C. |
| Immunogen | Recombinant Human CD141 protein |
| Abbre | CD141 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21], Functional Grade |
| Applications |
FCM
|
| Research Areas | CDs;Stem Cells;Kits;Lysates;Other;Cardiovascular Biology;Endothelial Progenitors Markers;Endothelial Cells;Coagulation |
| Cellular Localization |
Membrane
|
| Tissue Specificity |
Endothelial cells are unique in synthesizing thrombomodulin.
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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