Purified Anti-Human CD158e Antibody[DX9] (AN011520P)
| Alternate Names | AMB11, CD158 antigen-like family member E, CD158e antigen, CD158E1, CD158E1/2, CD158E2, CL11, CL2, HLA-BW4-specific inhibitory NK cell receptor, KI3L1, killer cell immunoglobulin like receptor, Killer cell immunoglobulin like receptor three domains, Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1, Killer cell immunoglobulin-like receptor 3DL1, KIR, KIR antigen 3DL1, KIR G1, KIR3DS1, Kirl1, Kirl2, Krl1, MGC119726, MGC119728, MGC126589, MGC126591, MHC class I NK cell receptor, Natural killer associated transcript 3, Natural killer cell inhibitory receptor, Natural killer-associated transcript 3, NK receptor, NK-associated transcript 10, NK-associated transcript 3, NK-associated transcript 3delIg1, NKAT10, NKAT-3, NKB1B, p70 killer cell inhibitory receptor, p70 natural killer cell receptor clones CL 2/CL 11, p70 natural killer cell receptor clones CL-2/CL-11, p70 NK receptor CL-2/CL-11, short cytoplasmic tail, NKB, NKAT, KIR3DL, CD158E, NKAT3, NKB1, KIR3DL1, NKB1, NKB1B, p70 |
| Clone | |
| Verified Samples | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | The DX9 monoclonal antibody specifically binds to CD158e1, also known as NKB1. CD158e1 functions as a killer cell inhibitory receptor (KIR) and is encoded by KIR3DL1 (Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail). CD158e1 is a 70 kDa glycoprotein that belongs to the Ig superfamily. It is expressed on a subset of natural killer cells and a small subset of T cells. Expression of CD158e1 has been observed to vary among individuals. KIR molecules specifically recognize a certain group of HLA class I antigens. Interaction of CD158e1 with specific HLA-B antigen on a target cell appears to inhibit cell-mediated cytotoxicity by delivering a negative signal that prevents lymphocyte activation. It is suggested that this MHC class I-KIR interaction works as a signaling mechanism that regulates NK and T-cell responses to antigenic challenge. |
| Immunogen | Recombinant Human CD158e protein |
| Abbre | CD158e |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21], Functional Grade |
| Applications |
FCM
|
| Cellular Localization |
Cell membrane
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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