Purified Anti-Human CD196/CCR6 Antibody[G034E3] (E-AB-F1158A)
![Purified Anti-Human CD196/CCR6 Antibody[G034E3] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: Unconjugated
APC Elab Fluor®647 Elab Fluor®700 Elab Fluor®Violet 450 FITC PE PE/Cyanine 7 Unconjugated Show More
| Verified Samples | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Isotype | Mouse IgG2b, κ |
| Host | Mouse |
| Reactivity | Human |
| Applications | FCM |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human CD196 protein |
| Abbre | CCR6 |
| Synonyms | DCR, DRY, GPR, CKRL, STRL, CKR-L, CMKBR, GPRCY, CC-CKR, C-C CKR, CCR, CCR6, BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22, BN 1, BN1, C C chemokine receptor type 6, C C CKR 6, CC chemokine receptor type 6, C-C chemokine receptor type 6, CC CKR 6, CC R6, CCCKR6, CCR 6, CD 196, CD196 antigen, Chemokine (C C motif) receptor 6, Chemokine (C C) receptor 6, Chemokine (CC motif) receptor 6, Chemokine (CC) receptor 6, Chemokine receptor 6, Chemokine receptor like 3, Chemokine receptor-like 3, CKR 6, CKR L3, CKR6, CMKBR 6, DCR 2, DRY 6, G protein coupled receptor 29, GPR 29, GPR CY4, GPRCY 4, GPR-CY4, G-protein coupled receptor 29, LARC receptor, Seven transmembrane receptor lymphocyte 22, STRL 22 |
| Swissprot | |
| Cellular Localization | Cell membrane |
| Concentration | ≥ 1 mg/mL |
| Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Purification Method | >98%, Protein A/G purified |
| Research Areas | Immunology, Signal Transduction, Cardiovascular |
| Clone No. | G034E3 |
| Conjugation | Unconjugated |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | CCR6, also known as CD196, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues. |
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