Purified Anti-Human CD223 Antibody[E29471] (AN015420P)
| Alternate Names | CD223 antigen, FDC protein, Lymphocyte activating 3, Lymphocyte activation gene 3, LAG, LAG3, CD223, LAG-3, Lymphocyte activation gene 3 protein, Protein FDC, FDC |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Human CD223 gene |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved in T-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223 negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells (NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated T-cells in acute conditions but high expression is maintained under tolerizing conditions. CD223 deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverse exhausted phenotypes, improve tumor rejection, and control viral load. |
| Immunogen | Recombinant Human CD223 protein |
| Abbre | CD223 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21], Functional Grade |
| Applications |
FCM
|
| Cellular Localization |
Cell membrane, Secreted
|
| Tissue Specificity |
Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| AN010470P | Purified Anti-Human CD223 Antibody[11C3C65] | 11C3C65 |
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