Purified Anti-Human CD26 Antibody[M-A261] (AN012940P)
| Alternate Names | ADABP Protein, ADCP2 Protein, CD26 Protein, DPPIV Protein, Human, TP103 Protein, DPP, dipeptidylpeptidase, dipeptidyl-peptidase, dipeptidyl peptidase, T-cell activation antigen CD, adenosine deaminase complexing protein, DPP4, ADABP, ADCP2, CD26, DPPIV, TP103, Dipeptidyl peptidase IV, ADCP-2, dipeptidyl-peptidase 4, dipeptidyl peptidase 4, DPP IV, dipeptidylpeptidase 4, T-cell activation antigen CD26, adenosine deaminase complexing protein 2, dipeptidylpeptidase IV, Dipeptidyl peptidase IV (DPP IV) |
| Clone | |
| Verified Samples | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes. |
| Immunogen | Recombinant Human CD26 protein |
| Abbre | CD26 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21], Functional Grade |
| Applications |
FCM
|
| Cellular Localization |
Cell junction, Cell membrane, Cell projection, Membrane, Secreted
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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