Purified Anti-Human FcεRIα Antibody[AER-37 (CRA-1)] (AN015530P)
| Alternate Names | FCER1, FcεRⅠ, FCER1A, FCE1A, FcERI |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Human FcεRIα gene |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | High affinity IgE receptor (FcεRI) plays a key role in IgE-mediated allergic immune response. FcεRI is a tetrameric receptor complex, which is composed of one α-subunit (FcεRIα), one β-subunit, and two γ-subunits. FcεRIα directly binds IgE with high affinity, while the β- and γ-chains are responsible for mediating intracellular signals. FcεRIα is a 50 kD transmembrane protein with Ig superfamily structure. It is primarily found on mast cells and basophils. Further studies have indicated that FcεRIα is also expressed on many inflammatory cells including cutaneuos Langerhans cells, dendritic cells, monocytes of patients with allergic disorders, platelets, bronchial epithelial cells, eosinophils produced in hypereosinophilic syndrome, and neutrophils from allergy-induced asthma patients. |
| Immunogen | Recombinant Human FcεRIα protein |
| Abbre | FcεRIα |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG2b, κ |
| Isotype Control | Purified Mouse IgG2b, κ Isotype Control[MPC-11], Functional Grade |
| Applications |
FCM
|
| Research Areas | Immunology |
| Cellular Localization |
Cell membrane
|
| Tissue Specificity |
Expressed in eosinophils.
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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