Purified Anti-Human IL-2 Antibody[MQ1-17H12], Functional Grade (E-AB-F12000)
![Purified Anti-Human IL-2 Antibody[MQ1-17H12], Functional Grade - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: None (AF/LE)
APC Elab Fluor®700 FITC None (AF/LE) PE Unconjugated Show More
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL-2 gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Isotype | Rat IgG2a, κ |
| Host | Rat |
| Reactivity | Human |
| Applications | ICFCM |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human IL-2 protein |
| Isotype Control | Purified Rat IgG2a, κ Isotype Control[2A3], Functional Grade |
| Abbre | IL-2 |
| Synonyms | IL2, IL-2, TCGF, lymphokine, Aldesleukin, IL-2lymphokine, interleukin-2, Proleukin, interleukin 2, involved in regulation of T-cell clonal expansion, T cell growth factor, T-cell growth factor, IL 2, IL2, Interleukin 2, interleukin2, Involved in regulation of T cell clonal expansion, Lymphokine, POIL2, T Cell Growth Factor, TCGF |
| Swissprot | |
| Cellular Localization | Secreted |
| Concentration | ≥ 1 mg/mL |
| Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Purification Method | >98%, Protein A/G purified |
| Research Areas | Immunology |
| Clone | MQ1-17H12 |
| Conjugation | None (AF/LE) |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Shipping | Ice bag |
| background | Interleukin-2 (IL-2) is a O-glycosylated, four alpha -helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils. Mature human IL-2 shares 56% and 66% aa sequence identity with Mouse and Rat IL-2, respectively. Human and Mouse IL-2 exhibit cross-species activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to prolifeRate and induces IL-2 and IL-2 R alpha synthesis. It contributes to T cell homeostasis by promoting the Fas-induced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes. IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells. Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
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