Purified Anti-Human/Monkey CD196/CCR6 Antibody[G034E3] (E-AB-F1158A)
For research use only.
Conjugation: Unconjugated
APC Elab Fluor®647 Elab Fluor®700 Elab Fluor®Violet 450 FITC PE PE/Cyanine 7 Unconjugated Show More
| Alternate Names | BN 1, BN-1, BN1, C C chemokine receptor type 6, C C CKR 6, C-C chemokine receptor type 6, C-C CKR, C-C CKR-6, CC chemokine receptor type 6, CC CKR 6, CC R6, CC-CKR, CC-CKR-6, CCCKR6, CCR, CCR 6, CCR-6, CCR6, CD 196, CD196, CD196 antigen, Chemokine (C C motif) receptor 6, Chemokine (C C) receptor 6, Chemokine (CC motif) receptor 6, Chemokine (CC) receptor 6, Chemokine receptor 6, Chemokine receptor like 3, Chemokine receptor-like 3, CKR 6, CKR L3, CKR-L, CKR-L3, CKR6, CKRL, CKRL3, CMKBR, CMKBR 6, CMKBR6, DCR, DCR 2, DCR2, DRY, DRY 6, DRY6, G protein coupled receptor 29, G-protein coupled receptor 29, GPR, GPR 29, GPR CY4, GPR-CY4, GPR29, GPRCY, GPRCY 4, GPRCY4, LARC receptor, Seven transmembrane receptor lymphocyte 22, STRL, STRL 22, STRL22 |
| Clone | |
| Verified Samples | Verified Samples in FCM: Human/Monkey peripheral blood lymphocytes |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | CCR6, also known as CD196, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues. |
| Immunogen | Recombinant Human/Monkey CD196 protein |
| Abbre | CCR6 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human;Monkey |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG2b, κ |
| Isotype Control | Purified Mouse IgG2b, κ Isotype Control[MPC-11] |
| Applications |
FCM
|
| Research Areas | Immunology;Signal Transduction;Cardiovascular |
| Cellular Localization |
Cell membrane
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Note: Data for this module come from published literature that cites this product, displaying other products used together in the same research paper.
Searching publications using CCR6 as the keyword shows that the gene above is closely associated with CCR6 in research. Results are sorted in descending order of research relevance. (The displayed numbers represent the number of publications in which both terms co-occur.)
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