Purified Anti-Human TNF-alpha Antibody[Infliximab297.rMAb] (AN007890P)
| Alternate Names | APC1, APC1 protein, Cachectin, DIF, Differentiation inducing factor, DIF、TNF-alpha、TNFA、TNFSF2, Macrophage cytotoxic factor, macrophage derived, member 2, Membrane Form, monocyte derived, soluble form, sTNFA, TNF, TNF alpha, TNF superfamily, TNF-a, TNF-alpha, TNFA, TNFSF, TNFSF2, TNLG1F, Tumor Necrosis Factor, Tumor necrosis factor alpha, Tumor Necrosis Factor Ligand Superfamily Member, Tumor Necrosis Factor Ligand Superfamily Member 2 |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Human TNF-α gene |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
| Immunogen | Recombinant Human TNF-alpha protein |
| Abbre | TNF-alpha |
| Swissprot | |
| Host | Human |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Human IgG1, κ |
| Applications |
FCM
|
| Research Areas | Cardiovascular Biology;Immunology;Signal Transduction;Cancer;Metabolism;Pyroptosis;Inhibition of Apoptosis;Cytokine and Growth Factors;Death Receptors Signaling Pathway;Insulin Signaling Pathway;Metabolic disorders;NF-kB Signaling Pathway;Pancreatic Cancer Markers;Tumor Biomarkers |
| Cellular Localization |
Cell membrane, Membrane, Secreted
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Note: Data for this module come from published literature that cites this product, displaying other products used together in the same research paper.
Searching publications using TNF-alpha as the keyword shows that the gene above is closely associated with TNF-alpha in research. Results are sorted in descending order of research relevance. (The displayed numbers represent the number of publications in which both terms co-occur.)
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