Purified Anti-Mouse CD18 Antibody[M18/2], Functional Grade (E-AB-F11130)
![Purified Anti-Mouse CD18 Antibody[M18/2], Functional Grade - 1](http://file.elabscience.com/assets/images/loading.png)
| Verified Samples | Verified Samples in FCM: C57/BL6 Mouse splenocytes |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells), Neut Reported in the literature |
| Isotype | Rat IgG2a, κ |
| Host | Rat |
| Reactivity | Mouse |
| Applications | FCM, Neut |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse CD18 protein |
| Isotype Control | Purified Rat IgG2a, κ Isotype Control[2A3], Functional Grade |
| Abbre | CD18 |
| Synonyms | Integrin beta, ITGB, CD18, Cell surface adhesion glycoproteins LFA-1/CR3/p150+95 subunit beta, Complement receptor C3 subunit beta, Integrin beta-2, Itgb2, &, beta-2 integrin-n |
| Swissprot | |
| Concentration | ≥ 1 mg/mL |
| Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Purification Method | >98%, Protein A/G purified |
| Research Areas | Cell Adhesion, Cell Biology, Immunology, Innate Immunity |
| Clone | M18/2 |
| Conjugation | None (AF/LE) |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Shipping | Ice bag |
| background | CD18 is a 95 kD protein, also known as integrin β2 subunit. It is expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and αXβ2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. The M18/2 antibody is able to block tumor cell metastasis and enhance cell adhesion. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
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