Purified Anti-Mouse CD279 Antibody[RMP1-14] (AN007850P)
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| Alternate Names | CD279 antigen, hPD 1, hPD l, Ly101, PD 1, Pdc1, PDCD 1, Programmed cell death 1 protein, Protein PD 1, Protein PD-1, Systemic lupus erythematosus susceptibility 2, hPD, mPD, Programmed Death, Programmed cell death, Programmed cell death protein, PDCD, hSLE, SLEB, PD-1, CD279, hPD-1, hPD-l, hSLE1, mPD-1, Programmed cell death 1, Programmed cell death protein 1, Programmed Death-1, SLEB2, Pd1, Pdcd1 |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse CD279 gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Background | Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
| Immunogen | Recombinant Human CD279 protein |
| Abbre | CD279 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Rat IgG2a, κ |
| Isotype Control | Purified Rat IgG2a, κ Isotype Control[2A3] |
| Applications |
FCM
|
| Cellular Localization |
Cell membrane
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| E-AB-F1131A | Purified Anti-Mouse CD279/PD-1 Antibody[29F.1A12] | 29F.1A12 |
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