Purified Anti-Mouse CD279/PD-1 Antibody[29F.1A12], Functional Grade (E-AB-F11310)
![Purified Anti-Mouse CD279/PD-1 Antibody[29F.1A12], Functional Grade - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: None (AF/LE)
APC Biotin Elab Fluor®647 Elab Fluor®700 Elab Fluor®Red 780 FITC None (AF/LE) PE PE/Cyanine 5.5 PE/Cyanine 7 PerCP/Cyanine 5.5 Unconjugated Show More
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse CD279 gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells), Block Reported in the literature, Neut Reported in the literature |
| Isotype | Rat IgG2a, κ |
| Host | Rat |
| Reactivity | Mouse |
| Applications | FCM, Block, Neut |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse CD279 protein |
| Abbre | CD279 |
| Synonyms | Programmed Death-1, PD-1 |
| Swissprot | |
| Cellular Localization | Cell membrane |
| Concentration | ≥ 1 mg/mL |
| Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Purification Method | >98%, Protein A/G purified |
| Research Areas | Cancer Biomarkers, Immunology, Inhibitory Molecules |
| Clone | 29F.1A12 |
| Conjugation | None (AF/LE) |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Shipping | Ice bag |
| background | CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| AN007850 | Purified Anti-Mouse CD279 Antibody[RMP1-14], Functional Grade | RMP1-14 |
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