Purified Anti-Mouse CD279/PD-1 Antibody[J43] (AN008860P)
| Alternate Names | CD279 antigen, hPD 1, hPD l, Ly101, PD 1, Pdc1, PDCD 1, Programmed cell death 1 protein, Protein PD 1, Protein PD-1, Systemic lupus erythematosus susceptibility 2, hPD, mPD, Programmed Death, Programmed cell death, Programmed cell death protein, PDCD, hSLE, SLEB, PD-1, CD279, hPD-1, hPD-l, hSLE1, mPD-1, Programmed cell death 1, Programmed cell death protein 1, Programmed Death-1, SLEB2, Pd1, Pdcd1 |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse CD279 gene |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts. |
| Immunogen | Recombinant Mouse CD279/PD-1 protein |
| Abbre | CD279 |
| Swissprot | |
| Host | Armenian Hamster |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Armenian Hamster IgG2, λ |
| Applications |
FCM
|
| Research Areas | Cancer Biomarkers;Immunology;Inhibitory Molecules |
| Cellular Localization |
Cell membrane, Secreted
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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