Purified Anti-Mouse CD366/Tim-3 Antibody[RMT3-23], Functional Grade (E-AB-F11920)
![Purified Anti-Mouse CD366/Tim-3 Antibody[RMT3-23], Functional Grade - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: None (AF/LE)
APC FITC None (AF/LE) PE Unconjugated Show More
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse CD366 gene |
| Isotype | Rat IgG2a, κ |
| Host | Rat |
| Reactivity | Mouse |
| Applications | FCM, Block, Neut |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse CD366 protein |
| Abbre | CD366/Tim-3 |
| Synonyms | TIM-, Tim3, TIM-3, Timd, Timd3, T-cell membrane protein, T-cell immunoglobulin mucin receptor, T-cell immunoglobulin and mucin domain-containing protein, Tim, TIM-, Tim3, Timd, TIM-3, Timd3, HAVcr-2, Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIMD-3, Havcr2, T cell immunoglobulin and mucin domain containing 3 protein, hepatitis virus cellular receptor 2 |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | ≥ 1 mg/mL |
| Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Purification Method | >98%, Protein A/G purified |
| Research Areas | Immunology, Inhibitory Molecules |
| Clone | RMT3-23 |
| Conjugation | None (AF/LE) |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Shipping | Ice bag |
| background | CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
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