Purified Anti-Mouse CD49d Antibody[R1-2] (AN004220P)
For research use only.
Conjugation: Unconjugated
APC Elab Fluor®488 Elab Fluor®647 FITC PE PE/Cyanine 7 PE/Elab Fluor®594 PerCP/Cyanine 5.5 Unconjugated Show More
| Alternate Names | ITGA, Itga4, VLA-4, &, alpha-4 integrin-n |
| Clone | |
| Verified Samples | Verified Samples in FCM: C57/BL6 Mouse splenocytes cell |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | CD49d is a 150 kD glycoprotein, also known as α4 integrin or VLA-4 α chain. It is a member of the integrin family, expressed on T and B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. CD49d is a heterodimer expressed with either of two β chains, β1 (CD29) or β7, to form the VLA-4 (integrin α4β1) or LPAM-1 (integrin α4β7) complexes. CD49d plays a critical role in adhesion and T cell costimulation. The primary ligands for CD49d are VCAM-1, MAdCAM-1, and fibronectin. |
| Immunogen | Recombinant Mouse CD49d protein |
| Abbre | CD49d |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Rat IgG2b, κ |
| Isotype Control | Purified Rat IgG2b, κ Isotype Control[LTF-2], Functional Grade |
| Applications |
FCM
|
| Cellular Localization |
Membrane
|
| Tissue Specificity |
Expressed in the media layer of the arterial wall (at protein level). Weakly expression in the thymus, spleen and mesenteric lymph nodes.
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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