Purified Anti-Mouse CD80 Antibody[16-10A1], Functional Grade (E-AB-F09920)
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For research use only.
| Alternate Names | Activation B7-1 antigen, B7, Cd80, T-lymphocyte activation antigen CD80 |
| Clone | |
| Leadtime | Order now, ship in 3 days |
| Background | CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Abbre | CD80 |
| Swissprot | |
| Host | Armenian Hamster |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype | Armenian Hamster IgG |
| Isotype Control | Purified Armenian Hamster IgG Isotype Control[PIP], Functional Grade |
| Applications |
FCM;Block
|
| Research Areas | Cell Biology;Costimulatory Molecules;Immunology;Neuroscience;Neuroscience Cell Markers |
| Concentration |
≥ 1 mg/mL
|
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Application References | Swadhinya Arjunaraja, et al. J Immunol. 2012 Jun 1;188(11):5238-46. |
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