Purified Anti-Mouse CD86 Antibody[GL-1], Functional Grade (E-AB-F09940)
![Purified Anti-Mouse CD86 Antibody[GL-1], Functional Grade - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: None (AF/LE)
APC Biotin Elab Bright™Violet 421 Elab Bright™Violet 510 Elab Bright™Violet 650 Elab Fluor®488 Elab Fluor®647 Elab Fluor®700 Elab Fluor®Violet 610 FITC None (AF/LE) PE PE/Cyanine 5.5 PE/Cyanine 7 PE/Elab Fluor®594 Unconjugated Show More
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse CD86 gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells), Block Block- Reported in the literature |
| Isotype | Rat IgG2a, κ |
| Host | Rat |
| Reactivity | Mouse |
| Applications | FCM, Block |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse CD86 protein |
| Abbre | CD86 |
| Synonyms | sCD86, CLS, ETC, T-lymphocyte activation antigen CD, Early T-cell costimulatory molecule, TS/A, Cd28l, Activation B7-2 antigen, B7, B7.2, B70, B7-2, Cd28l2, CLS1, Early T-cell costimulatory molecule 1, ETC-1, Ly58, Ly-58, MB7, MB7-2, T-lymphocyte activation antigen CD86, TS/A-2, Cd86, B7-2, Ly-58 |
| Swissprot | |
| Cellular Localization | Cell membrane, Secreted |
| Concentration | ≥ 1 mg/mL |
| Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Purification Method | >98%, Protein A/G purified |
| Research Areas | Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers |
| Clone | GL-1 |
| Conjugation | None (AF/LE) |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Shipping | Ice bag |
| background | CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
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